Linda Scoriels
Ph.D, HDR
Maîtresse de conférences
Université Paris Cité
Linda est chercheuse au LaPsyDÉ et enseignante en neurosciences cognitives à l'Institut de Psychologie de l’Université Paris Cité. Elle a fait un Magistère de Génétique, suivi d’un Master en Neurosciences Cognitives à Paris entre 2002 et 2005. Elle a ensuite réalisé un Doctorat en Neurosciences à l’Université de Cambridge, au Royaume-Uni, sous la direction de Peter Jones en 2010, suivi d’un premier postdoctorat. Puis, suite à l’obtention d’un financement « Jeunes talents » du gouvernement brésilien, Linda est partie à l’Université Fédérale de Rio de Janeiro (UFRJ), où elle a réalisé son 2ème postdoctorat, suivi d’un poste de maîtresse de conférences remplaçante à la faculté de médecine de l’UFRJ. À son retour à Paris, en 2021, elle a intégré l’équipe Krebs à l’Institut de Psychiatrie et Neurosciences de Paris, où elle a été nommée directrice scientifique de deux essais cliniques multicentriques en France. Elle a co-dirigé les thèses de Larissa Genaro (2018), Erica Woodruff (2018), Anna-Luiza Guimarães (2022), Valeria Lucarini (en cours), Delphine Yeh (en cours) sur le rôle des fonctions cognitives et émotionnelles dans les psychoses et le vieillissement.
Ses travaux de recherche portent sur la caractérisation biologique et environnementale des processus cognitifs et émotionnels liés au développement, aux troubles psychiatriques et au vieillissement. Elle cherche également à développer des stratégies pharmacologiques et digitales de renforcement cognitif chez ces différentes populations afin d’améliorer les processus cognitifs et émotionnels ainsi que le fonctionnement et la qualité de vie de ces personnes.
PUBLICATIONS
Frajerman, A., Urban, M., Rivollier, F., Plaze, M., Chaumette, B., Krebs, M.-O., & Scoriels, L. (2023). Abnormalities in one-carbon metabolism in young patients with psychosis. Frontiers in Psychiatry, 14, 1128890. https://doi.org/10.3389/fpsyt.2023.1128890 | More |
Mororó, L. G., Guimarães, A. L., Costa, A. C., Genaro, L., Cavalcanti, M. T., Scoriels, L., & Panizzutti, R. (2023). Association between motivation and engagement with changes in cognition and symptoms after digital cognitive training in schizophrenia. Schizophrenia Research, 251, 1–9. https://doi.org/10.1016/j.schres.2022.12.002 | |
Couturier, A., Chaumette, B., Kebir, O., Iftimovici, A., Krebs, E., He, Q., Jiao, C., Krebs, M.-O., Scoriels, L., & Frajerman, A. (2022). The impact of BDNF on the cognitive functions of ultra-high risk patients: An exploratory study. Schizophrenia Research, S0920-9964(22)00432-7. https://doi.org/10.1016/j.schres.2022.11.016 | |
Scoriels, L., Genaro, L. T., Keffer, S., Guimarães, A. L., Barros-Dumas, B., Mororó, L. G., Biagioni, T., Lucena, C., da Hora, T. R., Sahakian, B. J., Fisher, M., Vinogradov, S., & Panizzutti, R. (2022). Changes in emotion processing and social cognition with auditory versus visual neuroscience-informed cognitive training in individuals with schizophrenia. Schizophrenia Research, 241, 267–274. https://doi.org/10.1016/j.schres.2022.02.013 | |
Guimarães, A. L., Richer Araujo Coelho, D., Scoriels, L., Mambrini, J., Ribeiro do Valle Antonelli, L., Henriques, P., Teixeira-Carvalho, A., Assis Martins Filho, O., Mineo, J., Bahia-Oliveira, L., & Panizzutti, R. (2022). Effects of Toxoplasma gondii infection on cognition, symptoms, and response to digital cognitive training in schizophrenia. Schizophrenia (Heidelberg, Germany), 8(1), 104. https://doi.org/10.1038/s41537-022-00292-2 | More |
Frajerman, A., Scoriels, L., Kebir, O., & Chaumette, B. (2021). Shared Biological Pathways between Antipsychotics and Omega-3 Fatty Acids: A Key Feature for Schizophrenia Preventive Treatment? International Journal of Molecular Sciences, 22(13), Article 13. https://doi.org/10.3390/ijms22136881 | More |
Genaro, L. T., Santos, P. V., Mororó, L. G. C., Panizzutti, R., & Scoriels, L. (2021). The psychometric properties of the Behavioral Inhibition and Activation Systems motivational scale and a Brazilian Portuguese validation. Learning and Motivation, 75, 101743. https://doi.org/10.1016/j.lmot.2021.101743 | |
Scoriels, L., Genaro, L. T., Mororó, L. G. C., Keffer, S., Luiza, A., Guimarães, D. V., Ribeiro, P. V. S., Tannos, F. M., Novaes, C., França, A. I., Goldenstein, N., Sahakian, B. J., Cavalcanti, M. T., Fisher, M., Vinogradov, S., & Panizzutti, R. (2020). Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life. Schizophrenia Research, 222, 319-326. https://doi.org/10.1016/j.schres.2020.05.017 | More |
Toll, A., Bergé, D., Burling, K., Scoriels, L., Treen, D., Monserrat, C., Marmol, F., Duran, X., Jones, P. B., Pérez-Solà, V., Fernandez-Egea, E., & Mané, A. (2020). Cannabis use influence on peripheral brain-derived neurotrophic factor levels in antipsychotic-naïve first-episode psychosis. European Archives of Psychiatry and Clinical Neuroscience, 270(7), 851–858. https://doi.org/10.1007/s00406-020-01117-y | |
Scoriels, L., Zimbron, J., Garcia-León, N., Coll-Negre, M., Giro, M., Perez, J., Jones, P. B., & Fernandez-Egea, E. (2019). Cross-sectional study of diet patterns in early and chronic schizophrenia. Schizophrenia Research, 208. https://doi.org/10.1016/j.schres.2019.03.029 | |
Lennox, B. R., Palmer-Cooper, E. C., Pollak, T., Hainsworth, J., Marks, J., Jacobson, L., Lang, B., Fox, H., Ferry, B., Scoriels, L., Crowley, H., Jones, P. B., Harrison, P. J., & Vincent, A. (2017). Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: A case-control study. The Lancet Psychiatry, 4(1). https://doi.org/10.1016/S2215-0366(16)30375-3 | More |
Lennox, B. R., Pollak, T., Palmer-Cooper, E. C., Scoriels, L., Harrison, P. J., Jones, P. B., Lang, B., Crowley, H., Marks, J., & Vincent, A. (2017). Serum neuronal cell-surface antibodies in first-episode psychosis–Authors’ reply. The Lancet Psychiatry, 4(3). https://doi.org/10.1016/S2215-0366(17)30053-6 | |
Calderon, J., Flores, P., Aguirre, J. M., Valdivia, G., Padilla, O., Barra, I., Scoriels, L., Herrera, S., Gonzalez, A., & Massardo, L. (2016). Impact of cognitive impairment, depression, disease activity, and disease damage on quality of life in women with systemic lupus erythematosus. Scandinavian Journal of Rheumatology, 1–8. https://doi.org/10.1080/03009742.2016.1206617 | |
Scoriels, L., Avellar, M., Madeira, C., Vargas-Lopes, C., Marques, P., Dantas, C., Manhães, A. C., Leite, H., & Panizzutti, R. (2016). The effect of D-serine administration on cognition and mood in older adults. Oncotarget, 7(11). https://doi.org/10.18632/oncotarget.7691 | More |
Xu, M. K., Gaysina, D., Barnett, J. H., Scoriels, L., van de Lagemaat, L. N., Wong, a, Richards, M., Croudace, T. J., & Jones, P. B. (2015). Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders. Translational Psychiatry, 5(6), e593–e593. https://doi.org/10.1038/tp.2015.86 | More |
Scoriels, L., Salek, R. M., Goodby, E., Grainger, D., Dean, a M., West, J. a, Griffin, J. L., Suckling, J., Nathan, P. J., Lennox, B. R., Murray, G. K., Bullmore, E. T., & Jones, P. B. (2015). Behavioural and molecular endophenotypes in psychotic disorders reveal heritable abnormalities in glutamatergic neurotransmission. Translational Psychiatry, 5(January), e540–e540. https://doi.org/10.1038/tp.2015.26 | More |
Massardo, L., Bravo-Zehnder, M., Calderón, J., Flores, P., Padilla, O., Aguirre, J. M., Scoriels, L., & González, a. (2015). Anti-N-methyl-D-aspartate receptor and anti-ribosomal-P autoantibodies contribute to cognitive dysfunction in systemic lupus erythematosus. Lupus, 24(6), 558–568. https://doi.org/10.1177/0961203314555538 | |
Panizzutti, R., Scoriels, L., & Avellar, M. (2014). The co-agonist Site of NMDA-glutamate receptors: A novel therapeutic target for age-related cognitive decline. Curr Pharm Des, 20(32), 5160–5168. | |
Zandi, M. S., Deakin, J. B., Morris, K., Buckley, C., Jacobson, L., Scoriels, L., Cox, A. L., Coles, A. J., Jones, P. B., Vincent, A., & Lennox, B. R. (2014). Immunotherapy for patients with acute psychosis and serum N-Methyl d-Aspartate receptor (NMDAR) antibodies: A description of a treated case series. Schizophrenia Research, 160(1–3). https://doi.org/10.1016/j.schres.2014.11.001 | |
Calderón, J., Flores, P., Babul, M., Aguirre, J., Slachevsky, a, Padilla, O., Scoriels, L., Henríquez, C., Cárcamo, C., Bravo-Zehnder, M., González, a, & Massardo, L. (2014). Systemic lupus erythematosus impairs memory cognitive tests not affected by depression. Lupus, 2014, 1042–1053. https://doi.org/10.1177/0961203314536247 | |
Fernandez-Egea, E., Scoriels, L., Theegala, S., Giro, M., Ozanne, S. E., Burling, K., & Jones, P. B. (2013). Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 46, 25–28. https://doi.org/10.1016/j.pnpbp.2013.06.011 | |
Dean, a M., Goodby, E., Ooi, C., Nathan, P. J., Lennox, B. R., Scoriels, L., Shabbir, S., Suckling, J., Jones, P. B., Bullmore, E. T., & Barnes, A. (2013). Speed of facial affect intensity recognition as an endophenotype of first-episode psychosis and associated limbic-cortical grey matter systems. Psychological Medicine, 43(3), 591–602. https://doi.org/10.1017/S0033291712001341 | |
Scoriels, L., Jones, P. B., & Sahakian, B. J. (2013). Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain. Neuropharmacology, 64, 168–184. https://doi.org/10.1016/j.neuropharm.2012.07.011 | |
Scoriels, L., Barnett, J. H., Soma, P. K., Sahakian, B. J., & Jones, P. B. (2012). Effects of modafinil on cognitive functions in first episode psychosis. Psychopharmacology, 220(2), 249–258. https://doi.org/10.1007/s00213-011-2472-4 | |
Barnett, J. H., Scoriels, L., & Munaf, M. R. (2011). Reply to: With great power comes great responsibility: Meta-analytic proof for a timeless insight. Biological Psychiatry, 69(10). https://doi.org/10.1016/j.biopsych.2010.11.028 | |
Scoriels, L., Barnett, J. H., Murray, G. K., Cherukuru, S., Fielding, M., Cheng, F., Lennox, B. R., Sahakian, B. J., & Jones, P. B. (2011). Effects of modafinil on emotional processing in first episode psychosis. Biological Psychiatry, 69(5), 457–464. https://doi.org/10.1016/j.biopsych.2010.09.043 | |
Scoriels, L., Barnett, J., & Jones Peter, B. (2010). Modafinil for schizophrenia. Cochrane Database of Systematic Reviews, 9. https://doi.org/10.1002/14651858.CD008661 | |
Kirkbride, J. B., & Scoriels, L. (2009). Review of the 6th symposium for the search for the causes of schizophrenia, Sao Paulo, Brazil, 3-6 February 2009. European Archives of Psychiatry and Clinical Neuroscience, 259(8), 505–509. https://doi.org/10.1007/s00406-009-0025-1 | |
Barnett, J. H., Scoriels, L., & Munafò, M. R. (2008). Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism. Biological Psychiatry, 64(2), 137–144. https://doi.org/10.1016/j.biopsych.2008.01.005 | |
Mechawar, N., Saghatelyan, A., Grailhe, R., Scoriels, L., Gheusi, G., Gabellec, M.-M., Lledo, P.-M., & Changeux, J.-P. (2004). Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. Proceedings of the National Academy of Sciences of the United States of America, 101(26), 9822–9826. https://doi.org/10.1073/pnas.0403361101 | More |